ChemicalBook > CAS DataBase List > GDC-0853
GDC-0853
- Product Name
- GDC-0853
- CAS No.
- 1434048-34-6
- Chemical Name
- GDC-0853
- Synonyms
- GDC0853;CS-2241;EOS-61209;FENEBRUTINIB;GDC-0853;GDC 0853;GDC-0853 (RG7845);GDC-0853/Fenebrutinib;FENEBRUTINIB (GDC-0853);inhibit,Inhibitor,GDC0853,GDC 0853,Fenebrutinib,Btk,Bruton tyrosine kinase;2-1,6-Dihydro-3'-(hydroxymethyl)-1-methyl-5-5-(2S)-2-methyl-4-(3-oxetanyl)piperazin-1-ylpyridin-2-ylamino-6-oxo3,4'-bipyridin-2'-yl-3,4,7,8-tetrahydro-7,7-dimethyl-2H-cyclopenta4,5pyrrolo1,2-apyrazin-1(6H)-one
- CBNumber
- CB33142405
- Molecular Formula
- C37H44N8O4
- Formula Weight
- 664.8
- MOL File
- 1434048-34-6.mol
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GDC-0853 Property
- Boiling point:
- 936.3±65.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:20.0(Max Conc. mg/mL);30.08(Max Conc. mM)
DMSO:17.0(Max Conc. mg/mL);25.57(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.5(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);7.52(Max Conc. mM) - form
- A crystalline solid
- pka
- 13.15±0.10(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21346
- Product name
- GDC-0853
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $39
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21346
- Product name
- GDC-0853
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21346
- Product name
- GDC-0853
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $340
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21346
- Product name
- GDC-0853
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $647
- Updated
- 2023/06/20
TRC
- Product number
- F247550
- Product name
- Fenebrutinib
- Packaging
- 5mg
- Price
- $440
- Updated
- 2021/12/16
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GDC-0853 Chemical Properties,Usage,Production
Description
GDC-0853 is an orally bioavailable, selective, and reversible Bruton’s tyrosine kinase (BTK) inhibitor with IC50s ranging from 2-9 nM for basophil activation, B cell receptor activation, and constitutive p-BTK activity in whole blood lysates. In rats, treatment for longer than 7 days leads to pancreatic toxicity but it does not occur in mice or dogs, even at higher doses. Formulations containing GDC-0853 were well-tolerated in Phase I clinical trials and are in additional clinical trials for rheumatoid arthritis, lupus erythematosus, lymphoma, and leukemia.
Uses
Fenebrutinib is a selective and reversible oral small-molecular BTK inhibitor for the treatment of rheumatoid arthritis and systemic lupus erythematosus.
GDC-0853 Preparation Products And Raw materials
Raw materials
Preparation Products
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GDC-0853 Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4863
- Advantage
- 58
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4662
- Advantage
- 60
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
- ProdList
- 2738
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19553
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52927
- Advantage
- 58
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View Lastest Price from GDC-0853 manufacturers
Career Henan Chemical Co
- Product
- GDC-0853 1434048-34-6
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08